Inline Automation Optimized for Continuous Array Tape™
Global deployments throughout North & South America, Asia, and Europe are proving daily that the Array Tape™ Platform is transforming lab automation as we know it.
Achieve quality data with repeatable results in a flexible, high throughput system at a lower cost per data point. Douglas Scientific provides inline, modular instrumentation that is fully integrated and optimized for use with our revolutionary consumable, Array Tape™. This low cost, flexible microplate replacement enables automation of multiple laboratory processes on a single platform. The highly automated and robust system allows scientists to focus less on the automation and more on the data and other value added tasks.
The unique combination of the Array Tape™ consumable, Nexar® liquid handling and assay processing system, Soellex® PCR thermal cycler and Araya® inline fluorescent detection enables a continuous reel to reel process flow needed to maximize throughput and reduce costs.
Microplate Based Technology Without Manual Handling
The design of Array Tape™ and the modular inline platform maintains the flexibility of microplate-based technology while virtually eliminating manual handling and complex robotics. Indexing holes along the edge of Array Tape™ accurately position and continuously feed reaction wells through the Nexar® and Araya®. Each 96 or 384-well array in Tape is labeled with a unique barcode ensuring accurate identification of individual samples during and after processing.
Automatic Continuous Feed Process
Here is one example of how a process can be streamlined. Consider a SNP Genotyping Application:
Typical Processmicroplate-based workstations
Douglas Scientific Processusing Nexar®, Soellex® and Araya®
Step 1: Dispense 8 microliters a single 384- microplate at a time
Step 2: Seal the microplate
Step 3: Stack the microplates
Step 1: The Nexar® dispenses 800 µL sample and 800 uL reagent in the equivalent of 200 plates in a continuous strip of Array Tape™, seals it, and winds the samples on a dunker reel
|Process||Run microplates through PCR 16 or 32 at a time||Entire reel of Array Tape™ is loaded into the Soellex® water bath for approximately 90-120 minutes|
|Dry||Dry Microplate||Dry reel of Array Tape™ (optional on a custom centrifuge)|
|Detection||Scan Microplate (~ 1.5 – 2.5 minutes)||The Araya® scans the entire reel at a rate of 28 seconds per 384-well array|
|Plates per day:||150 microplates (384 wells)||400 arrays (384 wells)|
|Data points per day:||57,600||153,600|
|Lab processing time:||10 hours||8 hours|
Environmentally Conscious and Cost Effective
The environmental benefits of the Array Tape™ Platform have been evaluated based on plastic, reagent and energy consumption. The results include:
- Plastic required to manufacture a 384-well microplate is 7x greater (23.1g) than 384-well array in Array Tape™ (3.1g).
- Reagent storage, handling and disposal is reduced by 80-90% due to smaller reaction volumes in Array Tape™ (<800nL/well) versus microplates (5µL/well).
- The Soellex® simultaneously thermocycles up to 600 arrays, replacing 18 water baths (32 microplate capacity) that require 11x more energy (92.4kWh) or 150 block heaters (4 microplate capacity) that require 35x more energy (313.6kWh).
View all the results in our Array Tape Platform Provides HTP Screening with Reduced Plastic, Reagent and Energy Consumption poster.